Plasminogen, the Serum Proenzyme Activated by Factors from Cells Transformed by Oncogenic Viruses
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چکیده
منابع مشابه
Plasminogen, the serum proenzyme activated by factors from cells transformed by oncogenic viruses.
The serum factor that participates in the fibrinolytic activity associated with tumor and transformed cells has been purified by two independent methods. The chromatographic, electrophoretic, and biochemical properties of this molecule are consistent with the properties of the known fibrinolytic precursor, plasminogen. Purified plasminogen was isolated by afhnity chromatography from fetal bovin...
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An approximately 75% pure form of a human Mr approximately 54,000 plasminogen activator inhibitor from conditioned culture fluid of the fibrosarcoma cell line HT-1080 was obtained by a single step of chromatography on concanavalin A-Sepharose. The inhibitor inhibited human urokinase-type plasminogen activator (u-PA) and tissue-type plasminogen activator, but not plasmin. Rabbit antibodies again...
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Senescent human diploid cells (HDC) were fused to replicative transformed cells of different types, and DNA synthesis was monitored in the resulting heterodikaryons. Human cells transformed by simian virus 40 or adenovirus serotype 5 were able to induce DNA synthesis in senescent HDC nuclei in heterodikaryons. In contrast, carcinogen-transformed cells were not able to induce DNA synthesis in se...
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by oncogenic viruses [simian virus 40 (SV40) or jx)lyoma virus or sequential infection with both viruses], their susceptibility to changes caused by L-fucose was greatly reduced. Thus, virustransformed cells grown in the presence of L-fucose showed much less of a change in the morphology of individual cells, their pattern of association, their rate of growth, and incorporation of protein and RN...
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Macrophages obtained from the peritoneal cavity of untreated mice do not ordinarily synthesize plasminogen activator. However, induction of enzyme synthesis and secretion occurs when such macrophages are cultured in presence of conditioned medium from Con A-stimulated spleen cells. Plasminogen activator production by macrophages from endotoxin or thioglycollate medium-injected mice, which spont...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1974
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)42517-9